More interestingly, the capacity of trehalose to force macropinocytosis in NF1-deficient U373-MG glioblastoma cells is a novelty worth studying particularly in tumor cell types which are naturally prone to macropinocytosis, such as tumor cells with RAS hyperactivity due to oncogenic mutations in RAS itself or to loss-of-function of negative regulators of RAS. This evidence concerns the gene NF1 and glioblastoma.