A patient with a papillary tumor of the pineal region (CNS WHO grade 2; patient 25) and mTOR pathway activation in Phospho-IHC potentially due to allelic loss of PTEN and FGFR1 amplification was treated with everolimus with resulting SD until tumor progression after nine months (Fig. 3B, Table 1). This evidence concerns the gene FGFR1 and neoplasm.