On the other side, interestingly, it has been reported that the restoration of SMN in MNs can only determine slightly enhanced recovery and survival of SMA mice, while a winning strategy could be increasing SMN protein levels also in other cellular populations, such as astrocytes, which dysfunction is known to exacerbate SMA condition [28, 40, 41]. Here, SMN2 is linked to proximal spinal muscular atrophy.