By exerting an essential effect on the early phase of leukocyte adhesion and recruitment to the endothelium, SELP regulates the interaction between platelets and leukocytes [6]. Among various ligands of SELP, SELP glycoprotein ligand-1 (SELPLG) is the most extensively characterized and was shown to mediate the rolling of leukocytes [7]. Moreover, SELPLG and SELP participate in the onset of cardiovascular disorders [8, 9]. The gene discussed is SELPLG; the disease is cardiovascular disorder.