In the same category falls case 8 with an intrapulmonary lesion with co-expression of pan-cytokeratin and claudin4 and additionally alterations in TP53 and RB1. Classical neuroendocrine morphology and positive synaptophysin immunohistochemistry further support the diagnosis of an LCNEC. The gene discussed is TP53; the disease is large cell neuroendocrine carcinoma.