Among the predicted potential targets, EGFR, ESR1, AKT1, PTGS2, SRC, IL6, and VEGFA had high frequency, and were involved in several biological processes, including positive regulation of cell migration, positive regulation of kinase activity, response to oxidative stress, regulation of MAPK cascade, regulation of cell adhesion, which were closely related to the pathogenesis of PF. The gene discussed is ESR1; the disease is pemphigus foliaceus.