Genes related to the alleviation of RA and RA-associated lesions including Col11a2, Acsl6, Gpnmb and SNORA22, can be classified into category A. Among them, Col11a2 is a gene encoding type XI collagen, which plays a key role in maintaining the characteristics of the cartilage matrix36. This evidence concerns the gene COL11A2 and rheumatoid arthritis.