However, these results should be interpreted with caution for at least two reasons: i) Both HbA1c and hypoglycemia were analyzed in subgroups of the PS matched cohort without any further check on between-group imbalance and ii) pattern of baseline medications and an initial daily insulin dose of 40 U are poorly consistent with the expected profile of insulin-naïve patients [23]. Here, INS is linked to Hypoglycemia.