As the key initial step in the EMT, the downregulation of E-cadherin expression was observed in metastatic tumours, the transcriptional level of E-cadherin is repressed by several factors including, ZEB1 and Twist1, which have been identified as the effectors of β-catenin/TCF4 signalling in tumour invasiveness [36–38]. The gene discussed is ZEB1; the disease is neoplasm.