KDR and neoplasm: This is compatible with the work of Tate et al. who demonstrated that BMP7 treatment of cultured endothelial cells caused a decrease in the expression of Vegfr2 and Fgfr1 receptors, in endothelial cell migration and tube formation, but also a decrease in tumor vessels density in vivo after treatment with a recombinant protein for BMP7, attesting of an anti-angiogenic effect43.