To further prove that the block of the AAR pathway in combination with apatinib treatment will increase the cancer inhibition, the GCN2 knockdown in NSCLC cells was also used and the results showed that apoptosis rate was significantly increased in vitro and the tumor growth was slowed in vivo upon combined treatment (Fig. S6B–E). Here, EIF2AK4 is linked to non-small cell lung carcinoma.