SERPINB7 and psoriasis: Through transcriptomics and proteomics analyses, it was found that the loss of SerpinB7 affects the differentiation process of keratinocytes and the expression of calcium signaling pathway-related genes, and experiments have verified that the loss of SerpinB7 may inhibit keratinocytes by inhibiting the calcium ion concentration in keratinocytes, thereby inhibiting keratinocyte differentiate and promoting the expression of keratinocytes and inflammatory mediators, affecting the occurrence and development of psoriasis.