To explore the potential role of SerpinB7 in psoriasis, we subjected SerpinB7-/- mice to IMQ-induced psoriatic model, which exhibited a significant increase in the mouse Psoriasis Area and Severity Index (PASI), evaluates erythema, scales, and thickness [20] compared to those of SerpinB7+/+ mice (Fig. 3A). This evidence concerns the gene SERPINB7 and psoriasis.