These findings support that reduced NCOR1/RARA expression ratio and the subsequent lower CMA activity may be a common feature in RP patients and that interventions that stabilize the interaction of the co-repressor with the receptor, as the one described in this work, could be successful to restore the normal N-CoR1/RARα tone in the human disease. The gene discussed is RARA; the disease is retinitis pigmentosa 1.