Indeed, H3K27me3 content was shown to influence chromatin domain structures involving looping conformation to regulate Igf2 gene expression.22 Although other factors involved in regulating insulin expression in T1D pancreata will need to be considered, including incomplete processing of proinsulin,23 our data emphasises refractory H3K27me3 content associated with exocrine competency and default transcriptional suppression. This evidence concerns the gene INS and type 1 diabetes mellitus.