PDX1 and type 1 diabetes mellitus: In support of our hypothesis, we show that when pancreatic cells are stimulated with the EZH2 inhibitor GSK126, we restore the hallmark genes responsible for the maintenance of pancreatic progenitor identity, Pdx1, Ngn3, and Sox919 as well as significant expression of the Ins gene were observed in the non-diabetic and the T1D donors.