Importantly, EGFR, MET, EPHA2, MAPK1, MAPK3, and RPS6 kinase pathways were strongly dependent on FLCN in RPTEC and also strongly respond to FLCN reconstitution in this BHD tumor cell line, as highlighted in the UOK257 INKA rankings in orange (supplemental Fig. S6C). This evidence concerns the gene EPHA2 and neoplasm.