Additionally, considering the important role of TLR2 and TLR4 in both host-pathogen interactions (infections by K. pneumoniae could make the TLRs in human airway epithelial cells overexpressed, mainly TLR2 and TLR4 [41]) and activation of the innate immune response, molecular docking of constructed vaccine with these two Toll-like receptors was performed. The gene discussed is TLR4; the disease is infection.