ARG1 and root caries: In our study, KEGG enrichment analysis of the RNA-Seq-identified DEGs suggested that the C. albicans arginine biosynthesis pathway, including six upregulated genes (ARG1, ECM42, ARG3, ARG4, ARG5,6, ARG8) and one downregulated gene (CAR1), was remarkably changed in the dual-species biofilm and clinical root caries plaques (Fig. 3; Fig. S3).