Although not statistically significant compared to HEK293T expressing WT ACE2, some other ACE2 substitutions slightly affected the infection: T92I and Y515C enhanced VSVΔG*-SCoV-2 Alpha (P = 0.0953 and 0.0665, respectively), K26R and E37K reduced VSVΔG*-SCoV-2 Beta (P = 0.059 and 0.061), and T92I enhanced VSVΔG*-SCoV-2 Delta (P = 0.0557). The gene discussed is ACE2; the disease is infection.