Additionally, we established that cross-reactive DENV antibodies enhance ZIKV infection in KU812 cells, which is selectively coupled to enhanced chemokine ligand 5 (CCL5), interleukin 1β (IL-1β), and C-X-C motif chemokine ligand 10 (CXCL10) secretion and inhibited granzyme B (GrB) secretion. Here, GZMB is linked to Zika virus infectious disease.