The literature shows the same result of STK11 mutations co-occurring with KRASG12C at a high frequency and provides confidence in the ability of liquid biopsy to provide the same results as tissue assays.27 In contrast, TP53 and APC mutations were enriched in KRASG12C wild-type CRC, and MAP2K1 and PTEN co-occurred more frequently in patients with KRASG12C-mutant CRC. Here, PTEN is linked to colorectal carcinoma.