The role of the rat sarcoma viral oncogene (RAS) in tumorigenesis was discovered approximately 3 decades ago.1-3RAS activates and triggers downstream intracellular signaling cascades, including the mitogen-activated protein kinase, signal transducer and activator of transcription, and phosphoinositide 3-kinase pathways.4,5 Kirsten RAS (KRAS), one of three RAS isoforms, is the most commonly mutated proto-oncogene that has been identified in cancer.1,2,6 Despite its frequency and decades of research, the treatment of patients with KRAS mutations still remains an arduous challenge. Here, KRAS is linked to cancer.