BDH2 and fungal infectious disease: Second, the model simulation of BDH2 predicted an increased expression at the steady state due to its regulation by IRP, whereas experimental data showed BDH2 to be downregulated during infection (Fig. 6C and D), suggesting that the known biology of regulation of BDH2 (and, by extrapolation, the role of the mammalian siderophore 2,5-DHBA) during fungal infection is incomplete.