An N. gonorrhoeae strain, FA1090, with an inactivated transferrin receptor system is unable to cause infection in human males (52); TdfH allows gonococci to survive within neutrophil extracellular traps (NETs) (30); TdfF is required for gonococci to replicate within cervical epithelial cells (53); and ZnuD contributes to meningococcal interactions with epithelial cells, and znuD mutants are defective for dissemination in a mouse model (25, 54). Here, TFRC is linked to infection.