Furthermore, we observed regulation of signaling networks (i.e., adenylate kinase), metabolism (i.e., ATP phosphoribosyltransferase, aminotransferase, phosphoserine aminotransferase), and translation (i.e., 50S ribosomal protein), which support global changes to bacterial protein production driven by the presence of an established fungal infection. This evidence concerns the gene PROS1 and fungal infectious disease.