ACE2 and infection: While it is almost certain that the current SARS-CoV-2 VoC ravaging humanity are highly dependent on ACE2, as the high level of viral burden among the world’s population continues, increasingly in people with pre-existing Abs to SARS-CoV-2 through prior infection or vaccination, S2 hmAbs may provide protection against possible future variations in attachment receptor utilization by CoV.