Accumulation of pathogenic tau can disrupt neural connectivity and synaptic function, eventually leading to neural cell death and atrophy of several brain regions characteristic of diseases such as Alzheimer’s disease (AD), Corticobasal degeneration (CBD), Frontotemporal degeneration/dementia (FTD), Lewy Body disease (LBD) and Parkinson’s disease (PD). Here, MAPT is linked to Alzheimer disease.