A comparison of p16 expression with pT, pN, histologic grade, and patient prognosis in 128 analyzable vulvar carcinomas, 149 endometrioid endometrial carcinomas, 295 serous high grade ovarian carcinomas, 910 invasive breast carcinomas of no special type, 1245 urinary bladder carcinomas, 620 clear cell renal cell carcinomas, 414 germ cell tumors of the testis, 284 gastric adenocarcinomas, 396 pancreatic adenocarcinomas and 1365 colorectal adenocarcinomas revealed only few statistically significant associations (Table 2). The gene discussed is CDKN2A; the disease is invasive breast carcinoma.