NOTCH3 EGFr 1–6 group was the most important modifier of age at first stroke (hazard ratio, 2.45 [95% CI, 1.39–4.31]; P=0.002), lacune volume (odds ratio, 4.31 [95% CI, 2.31–8.04]; P=4.0×10-6), WMH volume (B=0.81 [95% CI, 0.60–1.02]; P=1.1×10-12), and peak width of skeletonized mean diffusivity (B=0.65 [95% CI, 0.44–0.87]; P=1.6×10-8). The gene discussed is NOTCH3; the disease is Stroke.