EGFR and snowflake vitreoretinal degeneration: The fact that EGFr 7–34 patients are milder is in line with the fact that EGFr 7–34 variants are frequent in the general population (1:300–1:1000), and in these population cohorts are associated with a very broad spectrum of cerebral SVD and even nonpenetrance.3-5 Therefore, EGFr 7–34 patients in CADASIL cohorts, although milder than EGFr 1–6 patients, still constitute the severe end of the EGFr 7–34 SVD spectrum.