TNNC1 and cardiomyopathy: Epigallocatechin-3-gallate (EGCG), a major catechin in green tea, had been reported to interact with a binding site for cardiac troponin C and to decrease calcium sensitivity.28,29 In vivo experimental models and clinical trials have demonstrated that EGCG improves diastolic dysfunction by correcting the calcium hypersensitivity of cardiac myofilaments in animal models and in human patients with cardiomyopathy.28,30 Thus, we assessed the effect of EGCG on calcium transients by FDSS/μCELL using the set of isogenic iPSC-CMs at 4 to 5 weeks after differentiation.