In human cancer specimens, IHC studies report that an increase in expression of NCL (without defining the subcellular localization) was associated with poor prognosis in pediatric and adult ependymoma [13, 14], hepatocellular carcinoma [15], non-small cell lung cancer [16], esophageal squamous cell carcinomas [17], and B cell lymphoma [18]. This evidence concerns the gene NUCLEOLIN and cancer.