It is possible that the decrease in endothelin‐1 seen in takotsubo cardiomyopathy is because of increased activity/density of endothelin type B receptors with vascular smooth muscle tone changes and a reduction in serum concentration of endothelin‐1, without affecting big‐endothelin‐1 levels. The gene discussed is EDNRB; the disease is Tako-tsubo cardiomyopathy.