REN and Tako-tsubo cardiomyopathy: We selected a representative cohort of patients with takotsubo cardiomyopathy with no confounding comorbidities or medications that could affect the renin‐angiotensin or endothelin systems, to investigate if the renin‐angiotensin and endothelin‐1 response pathways follow the same pattern of recovery as the left ventricular ejection fraction.