Moreover, as the recovery of von Willebrand factor halts angiogenesis, the influence of antithrombotics could lessen over time.23 Supporting this hypothesis, Dietrich et al26 recently reported that major late bleeding complications after TAVI were associated with unresolved acquired von Willebrand disease, while no relationship with the use of antithrombotics was found. This evidence concerns the gene VWF and Von Willebrand disease.