VWF and Von Willebrand disease: Aortic valve replacement has long been recognized as a favorable treatment option in patients with Heyde syndrome, as it resolves acquired von Willebrand disease.1 Not only does this dispel the bleeding diathesis of patients but also halts angiogenesis secondary to a lack of the von Willebrand factor.23 Both would result in a durable reduction of gastrointestinal bleeding episodes.