Four SNPs (rs10890208, rs3862218, and rs12030724 in YBX1. and rs11254419 in TRDMT1) were markedly associated with OS in an additive model of colorectal cancer patients after adjustment (HR = 1.43, 95% CI = 1.15–1.78, p = 0.001; HR = 1.36, 95% CI = 1.04–1.78, p = 0.025; HR = 0.73, 95% CI = 0.56–0.97, p = 0.028; HR = 1.30, 95% CI = 1.00–1.69, p = 0.047, respectively). This evidence concerns the gene TRDMT1 and colorectal cancer.