CD4 and neoplasm: Next, we identified six CD4+ T cell subsets within the mouse lung tumors, similar to those identified before as being involved in anti‐tumor efficacy (Figure 3B,C).[14] CD4+ Th1 cells overexpressed the marker genes Ifng, Tbx21, and Tnf;[15] CD4 Th17 T cells overexpressed Il17a, Il17f, and Rorc marker genes;[15] the two regulatory T cell (Treg) states, CD4IL2RAHI and CD4IL2RALO, showed high and low expression of Il2ra, respectively, and both showed high expression of Foxp3.