Several ClinVar P/LP variants were found in the non‐familial cancer groups, such as ATM c.1787CAA>C, p.K468X, and RAD51D, c.531T>TTA, p.K111IX, in 1MC and nMC; BRCA2 c.8242C>T, p.Ser2670Leu, and MSH6 c.3378C>T, p.Arg1076Cys, in 1MC; DNMT3A c.2982G>A, p.Arg882Cys, BLM c.1653G>GA, p.G512GX, FANCA c.1018TGTGA>T, p.TH329X, FANCI c.1926C>T, p.Arg614*, RNF213 c.14572G>A, p.Arg4810Lys, and WRN c.748TAA>T, p.K167X, in the nMC (Table S5). This evidence concerns the gene MSH6 and cancer.