Vacant Tumor microparticle induces macrophage conversion to M2 type via cGAS/STING/TBK1/STAT6 pathway, promoting M2 type macrophage proliferation and M1 type macrophage apoptosis, and M2 type macrophages, in turn, promote TRC proliferation, leading to tumor growth and metastasis.46 The gene discussed is STING1; the disease is neoplasm.