TBK1 and neoplasm: Vacant Tumor microparticle induces macrophage conversion to M2 type via cGAS/STING/TBK1/STAT6 pathway, promoting M2 type macrophage proliferation and M1 type macrophage apoptosis, and M2 type macrophages, in turn, promote TRC proliferation, leading to tumor growth and metastasis.46