Vacant Tumor microparticle induces macrophage conversion to M2 type via cGAS/STING/TBK1/STAT6 pathway, promoting M2 type macrophage proliferation and M1 type macrophage apoptosis, and M2 type macrophages, in turn, promote TRC proliferation, leading to tumor growth and metastasis.46 Here, STAT6 is linked to neoplasm.