Studies have found that patients with sepsis have changes in the innate and acquired immune systems, including accelerated apoptosis of immature macrophages, dendritic cells (DC), and natural killer (NK) cells, decreased activity of antigen-presenting cells and macrophages, an impaired CD4 + T lymphocyte response, and increased lymphocyte apoptosis [7, 8]. This evidence concerns the gene CD4 and Sepsis.