Furthermore, these factors were included to perform multivariate Cox analysis, and the result demonstrated that CLK2 expression (HR = 1.71, P = 0.019), age (HR = 2.70, P < 0.001), TNM stage (HR = 1.33, P = 0.03), local invasion (HR = 2.30, P = 0.003), and distant metastasis (HR = 2.30, P = 0.002) were independent prognostic factors for CRC (Table 3). The gene discussed is CLK2; the disease is colorectal carcinoma.