PIK3CA and central nervous system cancer: For example, AnnexinA5 is shown to activate the PI3K/Akt/NF-κB signaling pathway via targeting Snail to promote cell migration and invasion in vitro and tumorigenicity of glioma cells in nude mice [48]; 14-3-3β promotes the migration and invasion of human hepatocellular carcinoma cells through the PI3K/Akt/NF-κB signaling pathway [50].