In addition, circular RNAs (circRNAs) are also involved in the regulation of gene expression (acting as microRNA (miRNA) or RNA binding protein (RBP) sponges) ([44, 45]; M. [46]), and some circRNAs, such as circSMARCA5 and circHIPK3, are found to be good diagnostic biomarkers for glioblastoma multiforme [47], suggesting that circRNAs may also interact with MEG3 to play a role in glioblastoma progression. The gene discussed is MEG3; the disease is glioblastoma.