CXCR2 and urinary tract infection: On the other hand, Smithson et al. (66) found lower expression of neutrophil CXCR2 in 20 premenopausal women suffering from rUTI (without VUR) compared to 30 healthy female controls, suggesting that a low level of CXCR2 expression may increase the susceptibilities of premenopausal women to urinary tract infections.