TLR4 and bacterial infectious disease: Those limitations as well as age difference between studied cohorts might be the reason for opposite results obtained by Karoly and colleagues (42) who evaluated, based on the central role of heat shock protein 72 (HSP72) and TLR4 in innate response to bacterial infection, whether HSPA1B A1267G and TLR4 A896G genetic polymorphisms are risk factors for rUTI.