Our results showed that HIF-1α knockdown inhibited the migration and invasion and decreased the expression levels of VEGF, VEGFR1, VEGFR2, PI3K, and AKT in BPA-exposed CC cells, indicating that a low dose of BPA can activate HIF-1α to stimulate a high expression of VEGF, thereby targeting VEGFR to induce the PI3K/AKT signaling pathway function to accelerate tumor metastasis. This evidence concerns the gene KDR and neoplasm.