Because we discover that the level of Apo-B is correlated with many features, especially fasting insulin and IR, and a large population-based study proposed a non-fasting increase of 1mmol/L in Apo-B lipoprotein remnants is associated with a 2.8-fold causal increase in risk for ischemic heart disease (60, 61). This evidence concerns the gene INS and coronary artery disorder.