MAPT and Mental deterioration: Progressive cognitive decline (i.e., impaired memory)Preserved consciousnessDisrupted emotional controlDuration of at least 6 monthsIn-vivo markers of Alzheimer’s pathology:Corticospinal fluid (CSF): amyloid β, total tau, and phospho-tauPositron emission tomography (PET): Regional accumulation of amyloid and tau tracers, reduced mid-temporal and mid-parietal glucose metabolismStructural magnetic resonance imaging (MRI): Atrophy of medial temporal lobe, medial parietal cortex