Alicia M. Blessing et al. detected that androgen upregulated the expression of four essential autophagy genes, including ATG4B, ATG4D, ULK1, and ULK2. They validated the necessary role of ATG4B, ATG4D, ULK1, and ULK2 for the proliferation and metastasis of PCa [35]. This evidence concerns the gene ATG4B and posterior cortical atrophy.