The cancer stem cell-like trait analysis also indicated that sphere formation ability, embryonic stem cell markers OCT4, NANOG, and SOX2, and cancer stemness markers CD34, CD133, and ALDH1 expressions were repressed by miR-26a-5p, whereas the effects of miR-26a-5p were reversed by DNMT3A increasing, SFRP1 decreasing, and treating with HLY78 (Figures 5(g)–5(i)). The gene discussed is SOX2; the disease is cancer.