In patients with KIRC, univariate and multivariate COX analyses assessed the impact of multiple independent factors on OS, demonstrating that age, T-stage, lymph node metastasis, distant metastasis, histological grade, and GRAMD1A expression level could be considered as independent prognostic factors for patients (Table 1). This evidence concerns the gene GRAMD1A and metastatic malignant neoplasm in the lymph nodes.