MAPT and Alzheimer disease: Wild-caught and wild-type laboratory-outbred (but not laboratory-inbred) degu can spontaneously develop AD-like neuropathology including increased β-amyloid aggregates, tau hyperphosphorylation and neuroinflammation in the brain as part of their natural history (van Groen et al., 2011; Ardiles et al., 2012; Tarragon et al., 2013; Deacon et al., 2015; Salazar et al., 2016; Paushter et al., 2018).