As APOE status is the dominant driver of late-onset AD risk in humans (Serrano-Pozo et al., 2021), we characterized in detail the functional impact of a novel missense SNP in exon 3 (Mt4) of the degu Apoe (odApoe) and its association with late-onset AD-like phenotypes in this model. The gene discussed is APOE; the disease is Alzheimer disease.