This study analyzed rare and common variants of TMEM230, TMEM175, TMEM163, TMEM229B, TMEM108, and TMEM59 with gene-based and allele-based, respectively, through next-generation sequencing in a large Chinese PD cohort to better explore the genetic contribution of these six TMEM protein family genes in Chinese PD patients. The gene discussed is TMEM59; the disease is Parkinson disease.