Further studies found that both rare and common variants of TMEM175 were correlated to PD (Hopfner et al., 2020; Rudakou et al., 2021), and different common variants of TMEM175 may have opposite influences on stress-induced damage and α-synuclein accumulation in neurons, which complicated the specific role of TMEM175 in PD (Wie et al., 2021). This evidence concerns the gene TMEM175 and Parkinson disease.