To systematically investigate the genetic burden of six TMEM protein family genes, including TMEM230, TMEM175, TMEM163, TMEM229B, TMEM108, and TMEM59, in PD, we conducted a large case-control study in PD from the Chinese population, including FPD patients, sporadic early onset, and late-onset PD patients. Here, TMEM175 is linked to Parkinson disease.