TMEM59 and Parkinson disease: TMEM59 was found to mediate PD-related pathways, such as autophagy and dopamine system dysfunction (Boada-Romero et al., 2013; Liu et al., 2017); moreover, overexpression of TMEM59 in a Drosophila PD model ameliorated the phenotype of shortened lifespan, impaired locomotor activity, and loss of dopaminergic neurons by degrading a-synuclein (Zhang et al., 2018).