Similarly, another 4.7 KD polysaccharide Midi-GAGR also penetrated the BBB to reduce free reactive radicals and microglia cells, increased neurite outgrowth and phosphorylated cAMP responsive element binding protein, decreased hyperphosphorylated tau for neuroprotection in the transgenic AD mouse model (Makani et al., 2016). The gene discussed is MAPT; the disease is Alzheimer disease.