MAPT and Alzheimer disease: It is believed that the pathogenesis of AD includes the excessive aggregation of Aβ and neurofibrillary tangles formed by hyperphosphorylation of Tau protein (Zhang et al., 2021), release of pro-inflammatory cytokines (Bellucci et al., 2004), mitochondrial dysfunction (Kukreja et al., 2014), oxidative stress (Guix et al., 2012; Wahlster et al., 2013), apoptosis (Zhu et al., 2006), autophagy (Plaza-Zabala et al., 2017), and so on.