HD is characterized by a general shrinkage of the brain and degeneration of the striatum (caudate nucleus and putamen) due to the mutation of Huntingtin (HTT) gene (Jimenez-Sanchez et al., 2017); The symptoms of HD encompasses psychiatric conditions, cognitive defects, motor impairment (e.g., chorea; Huang et al., 2016). The gene discussed is HTT; the disease is Cognitive impairment.