MAPT and Alzheimer disease: In an adeno-associated virus serotype 2 (AAV2)-induced expression of human full-length Tau (hTau) in C57/BL6 mice to mimic AD tau pathology, C. pilosula polysaccharide significantly increased protein phosphatase-2A (PP2A) activity to attenuate tau phosphorylation in the hippocampus of mice (Zhang Q. et al., 2018).