CASP3 and Parkinson disease: Wang et al. reported that sulfated hetero-polysaccharides extracted from Saccharina japonica may had a “therapeutic anti-apoptosis” utility for PD by enhancing the phosphorylation of PI3K/Akt signaling pathway and impairing caspase-3 levels in H2O2-induced SH-SY5Y cells (Wang et al., 2017).