Tau is a microtubule-related protein that aggregates tubulin into microtubules, maintains complex neuronal cell microstructure promoting neuron maturation and regulating synaptic function (Dawson et al., 2001; Castellani and Perry, 2019), changes in synaptic distribution and interruption of interaction with synaptic proteins, damage neuron function and even lead to AD. Here, MAPT is linked to Alzheimer disease.