Gynostemma pentaphyllum Makino is a well-known edible and medicinal plant in Asia (Su et al., 2021), its extract polysaccharides decreased Bax/Bcl2 ratio, attenuated the activation of caspase-3/9, and improved PC12 cell viability of MPP+ – induced PD cell model (Deng and Yang, 2014). The gene discussed is CASP3; the disease is Parkinson disease.