Whereas dephosphorylation and lateralization of Cx43 at the plasma membrane are often induced by ischemia (Schulz et al., 2015), overexpression of Gja1-20k helps to maintain Cx43 localization at the intercalated discs in the setting of acute ischemia (Basheer et al., 2017). This evidence concerns the gene GJA1 and ischemia.