The outcomes showed that tumor-derived DNA activated the CXCL12-CXCR4 and CCL21-CCR7 axes in HCC, while sinoline hydrochloride inhibited the CXCl12-CXCR4 and CCL21-CCR7 axes in SK-Hep1 cells. This evidence concerns the gene CXCR4 and hepatocellular carcinoma.