CCR7 and neoplasm: WB analyses were completed to identify the level of Caspase 3, a protein associated with apoptosis, and the results were consistent with flow cytometry results, indicating that CXCR4 or CCR7 overexpression reduced tumor-derived DNA-induced apoptosis of HCC cells, while sinocine hydrochloride increased Caspase 3 levels (Figures 9G, H).