On the contrary, CXCR4 overexpression led to further decreased expression of ERK1/2 and MMP2/9, which also proved that CXCL12-CXCR4 axis or CCL21-CCR7C axis inhibition and sinoline hydrochloride had a synergistic anti-HCC effect. The gene discussed is MAPK3; the disease is hepatocellular carcinoma.